Some Negative effects can be significant. In case you knowledge any of the following signs or symptoms, simply call your medical professional immediately:

VIAGRA could influence just how other medicines operate, together with other medicines might impact the way VIAGRA will work, triggering Unwanted side effects. Specifically notify your healthcare supplier if you are taking any of the subsequent:

VIAGRA contains sildenafil, which is the same drugs found in One more drug known as REVATIO. REVATIO is used to treat a scarce disorder known as pulmonary arterial hypertension (PAH).

an erection that won't go away (priapism). Should you have an erection that lasts much more than 4 hrs, get clinical support right away. If It isn't addressed straight away, priapism can permanently problems your penis

VIAGRA will not safeguard you or your spouse from acquiring sexually transmitted conditions, including HIV—the virus that causes AIDS.

The suggest continuous point out quantity of distribution (Vss) for sildenafil is a hundred and five L, indicating distribution in the tissues. Sildenafil and its big circulating N-desmethyl metabolite are both of those approximately 96% bound to plasma proteins. Protein binding is impartial of total drug concentrations.

The effect on among the list of significant finish points, maintenance of erections after penetration, is proven in Figure 6, for that pooled success of five fastened-dose, dose-response scientific studies of larger than a single month length, showing response Based on baseline purpose. Final results with all doses are pooled, but scores showed greater enhancement in the fifty and 100 mg doses than at 25 mg. The sample of responses was comparable for another principal problem, the ability to achieve an erection ample for intercourse.

sudden Listening to minimize or Listening to reduction. Some individuals may possibly also have ringing of their ears (tinnitus) or dizziness. In case you have these signs and symptoms, end using VIAGRA and call a doctor without delay

g., creatinine clearance < 30 mL/min), and concomitant usage of erythromycin or powerful CYP3A4 inhibitors, plasma amounts of sildenafil at 24 several hours publish dose have been uncovered to be 3 to 8 occasions higher than Individuals noticed in healthier volunteers. Even though plasma levels of sildenafil at 24 hrs post dose tend to be lower than at peak concentration, it is actually unknown whether nitrates could be properly co-administered at this time place [see CONTRAINDICATIONS].

sudden eyesight reduction in one or both of those eyes. Sudden vision reduction in one or each eyes might be a indicator of a significant eye trouble identified as non-arteritic anterior ischemic optic neuropathy (NAION). Cease getting VIAGRA and call your healthcare provider straight away When you have any sudden vision loss

There have already been postmarketing experiences of bleeding occasions in sufferers who definitely have taken VIAGRA. A causal relationship in between VIAGRA and these functions has not been proven. In human beings, VIAGRA has no impact on bleeding time when taken by yourself or with aspirin.

20 subjects acquired VIAGRA fifty mg, but only 19 topics obtained matching placebo. One client discontinued the examine prematurely as a result of an adverse event of hypotension pursuing dosing with VIAGRA 50 mg. This patient were taking minoxidil, a more info powerful vasodilator, throughout the analyze.

Assessment of the security databases from controlled clinical trials showed no apparent difference in adverse reactions in patients having VIAGRA with and without the need of anti-hypertensive medication.

VIAGRA was revealed to potentiate the hypotensive results of nitrates and its administration in patients who use nitric oxide donors which include organic and natural nitrates or natural nitrites in any variety is for that reason contraindicated [see CONTRAINDICATIONS, DRUG INTERACTIONS, and CLINICAL PHARMACOLOGY].